Question:
How i can enhance Pioglitazone Hydrochloride dissolution profile results in combination with metformin HCl tablet ????
My response:
It is a common question/issue, i.e., people ask that they do not observe, expected or desired drug dissolution characteristics of a product but faster or slower. The simple and direct answer to such a question should be to change/adjust the product formulation/manufacturing attributes accordingly. In fact, that should be the only option or advice provided. Unfortunately, often as one does not know the formulation (usually not disclosed), thus no one can provide any useful advice in this regard.
On the other hand, at present, formulators have been convinced and/or trained to seek changes or adjustments in the dissolution method to obtain the characteristics they like to see. Such dissolution method adjustments are commonly promoted as science and method development practices. I call this “Fashionable Nonsense” as this practice is neither scientifically valid nor of any practical use (link). So please avoid such a practice.
To address such a problem/question, I would ask how you would know that your dissolution observations/results are correct. Is your method capable of providing accurate and/or valid dissolution results? That is, is the method you used been validated to determine the dissolution characteristics of a product? The answer is NO, i.e., none of the testers/methods, as recommended, are currently qualified and/or validated for dissolution testing. Thus, one cannot determine the dissolution characteristics of any product (link). The dissolution results that you are seeing are simply an illusion, not the actual dissolution characteristics of the product. Therefore, it is impossible to address the problem using currently recommended testers/methods. This is hard to believe, but it is a scientific fact.
Considering this background, I have suggested a modified stirrer, known as a crescent-shape spindle, based tester, which addresses the issues and provide far better dissolution testing and product characterization. You may read the details about it here. If you require further information, I will be happy to explain it further.
Best of luck!