[As part of a discussion on the LinkedIn Network group (Pharmacokinetics), I posted the following response. For the interest of those who do not participate in the LinkedIn Network or the particular group, I am posting the response on this blog as well. I hope that you will find the post useful.]
Thanks again, Simon: [Simon’s post is attached at the end of my response]
I do not think we are going in circles, but in my opinion, you are either not following my point or avoiding it. Let me explain it another time.
“IVIVC aims to Predict in vivo behavior from in vitro data.” This is incorrect. As the name (or “C”) implies, it is not a prediction exercise but an exercise in developing a correlation. For IVIVC, one has to have in vitro (i.e. dissolution) data and in vivo (plasma drug levels) data to relate them. No prediction whatsoever.