Years ago, I suggested a simple convolution approach using MS Excel Spreadsheet to predict blood/plasma drug levels from drug dissolution results. Several successful applications of such an approach have been published. A simple yet revolutionary approach! The model spreadsheet may be obtained from here.
Details of the approach are described in the publication (Saeed Qureshi (author), In Vitro-In Vivo Correlation (IVIVC) and Determining Drug Concentrations in Blood from Dissolution Testing – A Simple and Practical Approach, The Open Drug Delivery Journal, 2010, 4: 38-47 (link).
Obtain a copy of Helpful Notes (link) for pharmaceutical drug dissolution testing with several examples of using this (convolution) technique, along with articles describing the testing, its issues, and suggested solutions.