Defining a dissolution tester and need for a reference product

When one mentions or asks for a dissolution tester, immediately the following apparatuses come to mind: paddle, basket (rotating or reciprocating), and flow-through. The question is, why are these apparatuses known as dissolution testers? How do these apparatuses measure and describe a drug product’s dissolution (characteristics)? Consider the question in another way. An analyst has a tablet product, e.g., of acetaminophen, and would like to determine the dissolution characteristics of the tablets. Can any one of these testers provide the answer? Not really. Continue here

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