In vivo bioequivalence or simply bioequivalence is commonly referred to as an evaluation study conducted to establish the equality of mostly two oral products, such as tablets or capsules. The equality of two products (test vs reference) is established by comparing their blood drug concentration-time (C-t) profiles. The reason for selecting C-t profiles for such comparison is that as therapeutic effects depend on drug concentrations in blood i.e., if two or more products provide similar C-t profiles, then they will provide similar therapeutic effects as well. Thus they will be considered therapeutically bioequivalent or simply bioequivalent. Continue here.