Title: Limitations of Some Commonly Described Practices in Drug Dissolution Testing and Suggestions to Address These.
… In conclusion, it may be argued that most of the deficiencies/problems of current practices of dissolution may be related to poor hydrodynamics within the paddle and basket apparatuses, which also lack relevance to the physiological environment. The dissolution testing may significantly be improved if its role may clearly and objectively be established that the tests are to be conducted only to reflect in vivo dissolution characteristics of a product. This clarity of objective will provide an improved basis for selecting appropriate apparatuses and associated experimental conditions. In addition, such an objective will also reduce the significant workload by eliminating repeated IVIVC developments and other physiologically nonrelevant testing requirements. American Pharmaceutical Review, Jan/Feb. 2011. (link)