Predicting plasma drug levels does not require an IVIVC development. In fact IVIVC cannot be used for such predictions at all, as explained with an example from literature for gliclazide ER products

It is often suggested that conducting IVIVC studies, i.e., developing a relationship between in vitro (dissolution) and in vivo (plasma drug level), are necessary for developing dissolution tests capable of reflecting or predicting plasma drug levels. Unfortunately, this is not a correct view, as explained below:

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